Exercise Training and Fat Metabolism in Postmenopausal Women

Summary

Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.

Eligibility

Inclusion Criteria:

* Women
* Postmenopausal (50-75 yrs.)
* Obese (BMI 30-50 kg/m2)
* Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
* Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week)
* Non-smokers
* No hormone replacement therapy for at least the past two years.

Exclusion Criteria:

* Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week)
* Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
* Type 1 or type 2 diabetes
* Medical problems in which exercise is contraindicated, such as chronic infections
* History of, or currently presentation with, cancer, cardiovascular or respiratory disease
* Uncontrolled thyroid dysfunction, liver or renal dysfunction
* Taking any medication affecting lipid metabolism
* Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training
* Smokers and those with diagnosed eating disorders

Conditions4

Locations1 site

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