Neural Correlates of Impulsivity in Idiopathic REM Sleep Behavior Disorder

Summary

This study aims to investigate the neural correlates (structural changes, functional connectivity, and structural connectivity of brain structures in prefrontal cortex and basal ganglia) of impulsivity by measuring structures and the blood-oxygen-level-dependent signal of brain in response to impulsive tasks and task-free using functional Magnetic Resonance Image method among healthy controls, patient with prodromal PD (iRBD), and patients with PD.

Eligibility

Inclusion Criteria:

1. Age-and sex-matched with the groups;
2. Being capable of giving informed consent for participation of the study;
3. Without a personal history or a family history of PD or RBD;
4. A total score on REM Sleep Behavior Questionnaire (RBDQ-HK) less than 19, which is the suggestive cut-off of a diagnosis of RBD;
5. Absence of self-report dream enactment behaviors and RSWA as measured by v-PSG

Exclusion Criteria:

1. Having a history of ICD diagnosis or ICD symptom(s) assessed with Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS);
2. Presence of narcolepsy or other neurodegenerative diseases (except for PD group) that may give rise to RBD;
3. Presence of mood disorder which may have great impact on impulsivity;
4. A total score of the Montreal Cognitive Assessment (MOCA) ≤ 22 and the Clinical Dementia Rating (CDR) ≥ 1, indicating dementia;
5. Except for early medicated PD patients, if subjects from other groups who are on medication that may induce impulsivity, such as dopaminergic medication, will be excluded;
6. Contraindication to MRI (e.g., presence of implants or claustrophobia).

Conditions2

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