CHART Study of Coronary CT Angiography in Coronary Artery Disease

Summary

In a cohort of patients referred to coronary computed tomography angiography (CCTA), the investigators aim: 1. To describe the natural history of the coronary atherosclerotic plaque development and progression or regression, as well as the plaque characterization and phenotypes over time by CCTA among deferred coronary lesions 2. To explore the precursors of plaques leading to acute coronary syndrome (ACS) or chronic coronary syndrome (CCS) in deferred coronary lesions 3. To investigate prognostic implication of qualitative and quantitative plaque analysis of stenosis and plaque features, disease patterns, hemodynamic parameters, and fat metrics on CCTA along with physiologic assessment 4. To investigate the effects of different treatment strategies according to stenosis and plaque features, fat metrics on CCTA along with physiologic assessments.

Eligibility

Inclusion Criteria:

* Patients with an indication for CCTA.
* Qualified patients who have signed a written informed consent form.

Exclusion Criteria:

* Left ventricular ejection fraction \< 35%
* Acute ST-elevation myocardial infarction within 72 hours or previous coronary artery bypass graft surgery
* Abnormal epicardial coronary flow (TIMI flow \< 3)
* Planned coronary artery bypass graft surgery after diagnostic angiography
* Poor quality of CCTA or other reasons by core lab that are unsuitable for plaque, physiological or fat analysis
* Patients with a stent in the target vessel

Conditions2

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