Basal Plasma Lithium Levels and Suicidal Events

Summary

Suicidal behavior is a major public health issue and there are currently no specific treatments for it. However, lithium, the reference treatment for bipolar disorder, have been shown to be effective in preventing suicidal risk. Apart from drug treatments, lithium is present in our environment and its levels varies from one individual to another, depending, especially, on diet. Knowing that patients with a mood disorder generally have a poor lifestyle and a less rich and varied diet than the general population, variations in basal lithium levels can be expected in these patients.

Eligibility

Inclusion Criteria:

* 18 years old or over
* Current major depressive episode according to the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) criteria
* No lithium-based treatment over the last 12 months
* For suicide attempters/ideations only : suicidal event over the last 12 months
* For affective controls only : no suicidal event over the last 12 months

Exclusion Criteria:

* Lifetime diagnosis of schizoaffective disorder, schizophrenia or psychosis
* Pregnancy or breastfeeding
* Deprivation of freedom (by judicial or administrative decision)
* Legal protection measure (guardianship or curators)
* Inability to understand experimental procedures
* No affiliation to the French National Social Security System
* No consent to participate in the study

Conditions4

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