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Hybrid Ablation of Atrial Fibrillation in Heart Failure

RECRUITINGN/ASponsored by St. George's Hospital, London
Actively Recruiting
PhaseN/A
SponsorSt. George's Hospital, London
Started2022-06-25
Est. completion2026-05
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05411614

Summary

A randomised controlled trial to assess the efficacy of staged hybrid ablation when compared with standard catheter ablation in patients with non-paroxysmal atrial fibrillation (AF) and Heart Failure

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Age ≥ 18 years
* Persistent or Long-standing Persistent AF
* Dilated left atrium (at least moderately dilated)
* Suitable for either procedure
* LVEF \< 50%

Exclusion Criteria:

* Not yet optimised from a medical or lifestyle perspective for AF or heart failure
* Unable to provide written consent
* Previous open-heart surgery
* Active infection, oesophageal ulcer stricture or oesophageal varices
* Prior catheter ablation of atrial fibrillation (prior ablation for atrial flutter / supraventricular tachycardia or ventricular arrhythmia acceptable)
* Contraindication to anticoagulation, or active thrombus in the left atrium despite therapeutic anticoagulation
* Severe valvular heart disease
* Unstable coronary artery disease
* Uncontrolled ventricular arrhythmia
* Heart attack or stroke within the last 90 days
* Pregnant, breastfeeding, or women of childbearing age who plan to get pregnant within six months
* Severe concomitant condition or presence of an implanted device that would preclude the patient from undergoing trial procedures

Conditions7

Atrial ArrhythmiaAtrial FibrillationAtrial Fibrillation, PersistentHeart DiseaseHeart FailureLeft Ventricular (LV) Systolic DysfunctionPersistent Atrial Fibrillation

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