Impact of Sleep Duration on Immune Balance in Urban Children With Asthma

Summary

Urban children with asthma are at high risk for short sleep, due to an environment that jeopardizes both sleep and asthma management. Further, urban children with asthma suffer from altered immune balance, a key biological process contributing to individual differences in asthma morbidity and sleep health. In the proposed research, the researchers will examine the effects of shortened and recovery sleep on immune balance and associated changes in lung function in urban children with allergic asthma through an experimental design.

Eligibility

Inclusion:

* Children 7-11 years old
* Has physician-diagnosed asthma, per parent and pediatrician report
* Meets criteria for current persistent asthma with a current prescription for an asthma controller medicine
* Obtains 9.0-11.0 h of sleep per 24 h day in the past month
* Has a positive allergy skin test performed at the clinic visit
* Resides and attend school in one of the targeted urban areas (Rhode Island: East Providence, North Providence, Providence, Warwick, Cranston, Woonsocket, Central Falls, Pawtucket, Lincoln, Johnston. Massachusetts: Attleboro, North Attleboro, Fall River.
* Has a primary caregiver who speaks English

Exclusion:

* No asthma diagnosis
* No use of asthma controller medication
* Severe persistent asthma that is poorly controlled
* Diagnosis of additional pulmonary disease or medical condition or immune deficiency disorders
* Use of systemic steroids \<30 days of screening
* Asthma-related emergency department visit and/or asthma-related hospitalization in past 90 days
* Marked developmental delay, psychiatric conditions, academic/behavioral problems, learning disabilities
* Tanner stage 3-5 of pubertal development
* Diagnosed ADHD; Use of stimulants to treat ADHD
* An Apnea-Hypoxia Index \>5 (indicator of sleep disordered breathing)

Conditions4

Locations1 site

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