Early Pulmonary Dysfunction in Childhood Cancer Patients

Summary

This longitudinal, prospective, multicentre study is to monitor lung function prospectively in childhood cancer patients after diagnosis. The impact of cancer treatment on pulmonary dysfunction non-invasively using lung function, lung imaging and breath analysis as well as clinical symptoms using a questionnaire will be assessed at different time points.

Eligibility

Inclusion Criteria:

* at least one of the following cancer treatments:

  * chest radiation
  * treatment with any kind of chemotherapy
  * hematopoietic stem cell transplantation (HSCT)
  * thoracic surgery
* consent for Childhood Cancer Registry (ChCR) registration

Exclusion Criteria:

* no signed informed consent
* Operation outside the chest area as only cancer treatment
* Relapsed cancer (patients who develop relapse during the study will not be excluded)
* In addition for MRI and lung function tests:

  * Subjects who are respiratory insufficient and cannot perform a lung function test (less than 92% O2 saturation; under O2 therapy)
  * Pregnant
  * MRI measurement not possible without sedation
  * Metal (e.g. pacemaker) in the body

Conditions3

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