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Modulating Exercise Dosage to Improve Concussion Recovery

RECRUITINGPhase 2Sponsored by University of Colorado, Denver
Actively Recruiting
PhasePhase 2
SponsorUniversity of Colorado, Denver
Started2022-08-05
Est. completion2027-02-01
Eligibility
Age13 Years – 18 Years
Healthy vol.Accepted
Locations3 sites

Summary

Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity level) initiated within 14 days of concussion results in faster symptom resolution, altered physiological function, or reduced secondary sequalae. Findings from this research will lead to more rigorous and precise rehabilitation guidelines and improved understanding about how exercise affects neurophysiological function among adolescents with concussion.

Eligibility

Age: 13 Years – 18 YearsHealthy volunteers accepted
Inclusion Criteria:

* 13-18 years of age
* Post-Concussion Symptom Scale (PCSS) score \>10 to ensure participants are not recovered by enrollment
* Concussion diagnosis by a sports medicine physician

Exclusion Criteria:

* Pre-existing neurological disorders
* Exercise contraindications
* Concussion \<6 months before enrollment (excluding the current injury)

Conditions7

Aerobic ExerciseAnxietyConcussion, BrainDepressionDepression, AnxietyInflammationTreatment

Locations3 sites

Colorado

1 site
University of Colorado Denver
Aurora, Colorado, 80045
David R Howell, PhD7207771502ConcussionResearch@cuanschutz.edu

Massachusetts

2 sites
Boston Children's Hospital
Boston, Massachusetts, 02115
Danielle Hunt, MS
Spaulding Rehabilitation Hospital
Cambridge, Massachusetts, 02138
Andrew Taylor, PhD

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