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Percutaneous Needle Fasciotomy +/- Corticosteroid Injection for Dupuytren's Contracture

RECRUITINGPhase 4Sponsored by Regionshospitalet Silkeborg
Actively Recruiting
PhasePhase 4
SponsorRegionshospitalet Silkeborg
Started2023-01-10
Est. completion2025-12
Eligibility
Age45 Years – 99 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05440240

Summary

Comparing percutaneous needle fasciotomy +/- corticosteroid injection for Dupuytren's contracture affecting metacarpophalangeal joints. A clinician-initiated, multicenter, randomized controlled trial.

Eligibility

Age: 45 Years – 99 YearsHealthy volunteers accepted
Sufficient correction of metacarpophalangeal (MCP) joint during the PNF treatment, defined as \<20° passive extension deficit (PED), is a prerequisite for inclusion.

Inclusion Criteria:

* Dupuytren contracture (DC) of ≥ 20° PED in MCP joint measured with a goniometer
* DC of either II-V finger
* Well-defined/palpable cord

Exclusion Criteria:

* Legally incapacitated
* Previous study inclusion with another finger ray
* Isolated proximal interphalangeal (PIP) or distal interphalangeal (DIP) joint contracture, defined as MCP joint contracture \< 20° PED regardless of the deficit in the PIP or DIP joint
* Previous hand surgery of the affected finger for any reason
* Known allergy to the study medication
* Anticoagulant therapy (Acetylsalicylic acid is NOT an exclusion criterion)
* Pregnant or lactation
* Insulin dependent diabetes mellitus
* Ongoing systemic infection or local infection at the site of the procedure
* Rheumatoid arthritis
* Amyloidosis or mucopolysaccharidosis
* Unable to communicate, cooperate or participate in follow-up

Conditions13

CancerConnective Tissue DiseasesContractureDupuytren ContractureDupuytren's DiseaseFibromaJoint DiseasesMusculoskeletal DiseasesNeoplasm, Fibrous TissueNeoplasms

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