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Disease Activity Biomarkers in Patients With Systemic Lupus Erythematosus

RECRUITINGSponsored by Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Actively Recruiting
SponsorCliniques universitaires Saint-Luc- Université Catholique de Louvain
Started2014-06-16
Est. completion2022-12-31
Eligibility
Age18 Years – 70 Years
View on ClinicalTrials.gov →

NCT05443516

Summary

The aim of this research project is to better understand the origin and clinical significance of two lupus-specific "genetic signatures" (IFN signature and plasma cell signature) in patient subgroups with well-defined clinical characteristics. Our aim is to correlate these genetic signatures with cell activation profiles and the production of specific cytokines in different populations from whole blood and in short-term cultures of these circulating cells.

Eligibility

Age: 18 Years – 70 Years
Inclusion Criteria:

* Fulfilment of the EULAR/ACR classification criteria of SLE.
* 18 years of age or above.
* Incident or Flare biopsy-proven proliferative or membranous LN

Exclusion Criteria:

* Antiphospholipid syndrome nephropathy (APSN).
* Pregnancy at baseline (pregnancy during follow-up will not lead to exclusion).
* Anticipated non-adherence to therapy.
* Medical conditions interfering with outcome evaluations.
* Inability to read and/or sign the informed consent form.

Conditions2

LupusLupus Nephritis

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