Targeting LOXL2 and Cardiac Fibrosis for Post-acute Heart Failure Treatment- A Prospective Study

Summary

A previous study demonstrated that a multidisciplinary cardiac rehabilitation (CR) program was associated with reduced medium- to long-term all-cause mortality in a retrospective propensity score-matched study. The investigators will further investigate the predictors including LOXl2, cardiac MRI, and endothelial function that will benefit from a successful CR.

Eligibility

Inclusion Criteria:

1. Patients must give written informed consent before any assessment is performed.
2. Inpatients \>= 20 years of age, male or female.
3. Patients with a diagnosis of heart failure New York Heart Association (NYHA) class II-IV with BNP \>=100 pg/mL or NT-porBNP \>= 400 pg/mL ( \>= 900 pg/mL if concomitant atrial fibrillation)
4. Left ventricular ejection fraction \<= 40% by echocardiography or other methods

Exclusion Criteria:

1. Estimated survival time \< 6 months
2. Long-term bedridden for more than 3 months
3. Cannot tolerate exercise test due to muscular skeletal disorder.
4. Cannot cooperate all functional studies
5. Ventilator dependent
6. Terminal heart status
7. Family rejects to participate in this project
8. Primary severe valvular heart disease

Conditions2

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