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Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease

RECRUITINGN/ASponsored by University of Minnesota
Actively Recruiting
PhaseN/A
SponsorUniversity of Minnesota
Started2016-08-25
Est. completion2026-12-31
Eligibility
Age21 Years – 89 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT05557864

Summary

This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practice by providing a potential strategy to these medically intractable symptoms.

Eligibility

Age: 21 Years – 89 YearsHealthy volunteers accepted
Inclusion Criteria:

* diagnosis of idiopathic PD
* have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN)
* Existing 7T brain imagery

Exclusion Criteria:

* history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs
* other significant neurological disorder
* history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR)
* post-operative complications or adverse effects

Conditions1

Parkinson's Disease

Locations1 site

University Of Minnesota
Minneapolis, Minnesota, 55455
Colum MacKinnon, PhDcmackinn@umn.edu

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