BreathinG-induced Myocardial and Cerebral Perfusion in Anxiety Disorders

Summary

This study aims to view variations in MRI measurements of the heart and the brain in people with anxiety versus healthy volunteers. The MRI measurements used will be Oxygenation-Sensitive Cardiac MRI (OS-CMR), a recent type of MRI which is safe, fast, and non-invasive.

Eligibility

Inclusion Criteria:

Patient population:

Age 18-55,

* Confirmation of an anxiety disorder as identified by the PSWQ,
* No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system (except anxiety and depression)
* Non-smoker

Healthy Volunteers:

* Age 18-55
* No known, current or history, of significant medical conditions that may affect or directly involve the neurological, cardiovascular or respiratory system
* Non-smoker

Exclusion Criteria:

* General MRI contraindications: pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, pregnancy
* History of significant neurological disease or illness that is not anxiety (e.g. Dementia, stroke)
* Hemodynamically unstable conditions
* Significant or uncontrolled arrhythmias
* Severe pulmonary disease
* Recent (\<90 days) myocardial infarction
* Recent (\<90 days) surgery or coronary intervention
* Consumption of caffeine (caffeinated beverages, coffee, tea, cocoa, chocolate) within 12h of the exam
* Use of benzodiazepines or other short-acting anxiety medications (\<1 day)

Conditions3

Browse More Trials