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Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients

RECRUITINGSponsored by Jona Hattangadi-Gluth
Actively Recruiting
SponsorJona Hattangadi-Gluth
Started2015-01
Est. completion2026-12
Eligibility
Age18 Years – 99 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT05576103

Summary

In this proposal, the investigators introduce a novel, translational study to prospectively examine primary brain tumor patients undergoing fractionated radiation therapy to the brain. Quantitative neuroimaging, radiation dose information, and directed neurocognitive testing will be acquired through this study to improve understanding of cognitive changes associated with radiation dosage to non-targeted tissue, and will provide the basis for evidence-based cognitive- sparing brain radiotherapy.

Eligibility

Age: 18 Years – 99 YearsHealthy volunteers accepted
Inclusion Criteria:

1. Patients 18 years or older
2. Karnofsky performance status (KPS) ≥70
3. Life expectancy of ≥1 year
4. Primary brain tumor patients who will receive fractionated partial brain RT
5. Able to complete neurocognitive assessments

Exclusion Criteria:

1. Inability to undergo MRI with contrast
2. Prior brain RT

Conditions5

CancerGliomaMeningiomaPrimary Brain TumorSchwannoma

Locations1 site

Moores Cancer Center
San Diego, California, 92037
Lara J Rose858-822-6575s4medina@health.ucsd.edu

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