Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure

Summary

* Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome. * Describing immuno-inflammatory profiles associated with massive vascular leakage during those three forms of circulatory failure in humans

Eligibility

Inclusion Criteria:

1. Informed consent from patient or a legal representative/family member/close relative. The patient will be asked to give his/her consent for the continuation of the trial when his/her condition will allow.
2. Affiliation to social security (AME excluded)
3. Patient with one of the circulatory failures described below:

   * septic shock
   * cardiogenic shock
   * post-resuscitation syndrome
   * Cardiogenic shock:

     * Need for a catecholamine support to maintain mean arterial pressure\>65 mmHg, AND
     * Cardiac index \<2 L/min/m2 or left ventricular ejection fraction (LVEF)\<35%, AND
     * Lactate \>2.0 mmol/l
   * Post-resuscitation syndrome:

     * Cardiac arrest (absence of spontaneous respiration, palpable heartbeat, and responsiveness to stimuli\> 1 min) with a compatible electrocardiogram (asystole/pulseless electrical activity/ventricular tachycardia), AND
     * Need for a catecholamine support to maintain mean arterial pressure\>65 mmHg, AND
     * Lactate \>2.0 mmol/l
   * Septic shock:

     * Suspected or proven bacterial infection
     * Need for a vasopressor support to maintain mean arterial pressure\>65 mmHg
     * Lactate \>2.0 mmol/l
     * Cardiac index\>3L/min/m2 or LVEF\>40%

Exclusion Criteria:

1. Onset of shock (catecholamine infusion) \>12 hours prior to inclusion
2. Age \<18 year old
3. Pregnancy

Conditions4

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