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Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors

RECRUITINGSponsored by Indiana University
Actively Recruiting
SponsorIndiana University
Started2022-10-11
Est. completion2026-12
Eligibility
Age18 Years – 99 Years
SexMALE
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT05611307

Summary

Late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant

Eligibility

Age: 18 Years – 99 YearsSex: MALEHealthy volunteers accepted
Inclusion Criteria

* Patients \>18 years of age
* Patients will be recruited only if cancer-free at clinical evaluation time.
* For the cases a confirmed TC diagnosis who received one or more cycles of CBCT-based chemotherapies (CBCT group, Arm 2)
* For the cases with a confirmed TC diagnosis who received one or more cycles of CBCT-based chemotherapies and underwent BMT for relapsed refractory disease (CBCT \& BMT group, Arm 3).
* For the comparison cohort, biopsy-proven TC patients who had surgery for or surveillance of their testicular cancer and never received CBCTCBCT or BMT (surgical/surveillance, Arm 1)

Exclusion Criteria

* Prior known myocardial infarction (MI), atherosclerotic cardiovascular disease (ASCVD)
* Significant renal disease (GFR\<40)
* Allergy to iodinated contrast
* Antecedent chemotherapy for another primary cancer.

Conditions10

ASCVDBone Marrow Transplant ComplicationsCancerCisplatin Adverse ReactionCoronary Artery DiseaseHeart DiseaseHypogonadism, MaleLipid DisorderSurvivorshipTesticular Cancer

Locations1 site

Indiana University
Indianapolis, Indiana, 46202
Elizabeth Rowe(317) 278-1185rowee@iu.edu

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