Plan of the Day Radiotherapy

Summary

The study objectives are to improve the treatment of LACC patients and to increase knowledge of the potential benefit of the plan-of-the-day concept on side effects during and after radiotherapy.

Eligibility

Inclusion Criteria:

* Histologically confirmed cervical cancer eligible for definitve radiochemotherapy
* FIGO stage IB1-IVa
* Over 18 years
* Speaks and understands Norwegian or English.
* ECOG 0-2
* Histology: Squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma
* Ability to understand and fill in patient questionnaires, and willing to sign a written informed consent
* Large movers (LM), fundus movement ≥2,5 cm.

Exclusion Criteria:

* Evidence of distant metastasis. Suspicious paraaortic lymphnodes below the renal vessels is allowed if they are covered by the radiation field
* Patients with previous surgery for their cervical cancer
* Uncontrolled intercurrent somatic illness.
* Psychiatric illness /social situations limiting study compliance
* Prior radiotherapy to the pelvis
* Patients who are pregnant or breastfeeding is excluded due to risk of teratogenic and abortifacient effects of radiotherapy and cisplatin, and the potential risk of adverse effect of nursing infants
* Patients under current treatment for other invasive s except non-melanoma skin cancers
* Nephrostomy
* Patients with inflammatory bowel disease

Conditions2

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