FMRI-neurofeedback in Depression

Summary

Previous studies with fMRI-neurofeedback in depression have demonstrated a good safety profile and considerable symptom reduction. The goal of this clinical trial is to compare fMRI-neurofeedback plus standard care with standard care in patients with depression. Participants will either receive standard care, or standard care plus a fMRI neurofeedback training, consisting of 5 neurofeedback training sessions. Symptom severity will be assessed before, immediately after and 6 months after the intervention.

Eligibility

Inclusion Criteria:

* Diagnosis of a depressive disorder (ICD-10: F32 or F33)
* Has been on stable antidepressant medication (single or combination treatment) for at least 4 weeks
* Current depression (QIDS \>= 17)
* If required to meet recruitment targets the minimum entry score will be reduced QIDS \>= 13 (i.e. still corresponding to a moderate level of depression)

Exclusion Criteria:

* Exclusion criteria for MRI (e.g. cardiac pacemaker, certain metallic implants)
* History of psychotic disorder bipolar disorder, or psychotic depression
* Current use of illegal drugs (any in the last four weeks)
* Current excessive alcohol consumption that interferes with daily functioning
* History of neurological disease that could influence the fMRI signal and/or the anatomical alignment (e.g. territorial stroke, multiple sclerosis, brain tumour)

Conditions2

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