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Vaginal Microbiome and HPV Pre-malignant and Cervical Dysplasia

RECRUITINGSponsored by Hadassah Medical Organization
Actively Recruiting
SponsorHadassah Medical Organization
Started2022-11-09
Est. completion2025-12-30
Eligibility
Age25 Years – 70 Years
SexFEMALE
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05640700

Summary

In this study, the investigators will prospectively collect, analyze and integrate information regarding vaginal microbiome composition and HPV presence in women with cervical pathologies (high-grade CIN and CC) and controls, to construct a large dataset from patients with pre-cancerous cervical lesions and healthy women, to evaluate the personalized contribution of the vaginal microbiome to the CIN-CC sequence.

Eligibility

Age: 25 Years – 70 YearsSex: FEMALEHealthy volunteers accepted
Inclusion Criteria:

* Age 25-70
* Attended the clinic for a Pap smear or colposcopy

Exclusion Criteria:

* Patient does not approve sample collection
* Usage of antibiotics in the month prior to clinic visit
* Usage of any vaginal preparation or medication in the week prior to sample collection (anti-fungal, spermicides, lubricant etc.)
* Menstruation
* Pregnancy

Conditions5

CancerCancer Cervix UterusCervical DysplasiaHuman Papilloma VirusVaginal Flora Imbalance

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