Radiosurgery Induced Ototoxicity in Patients Treated for a Vestibular Schwannoma
NCT05641441
Summary
The investigators aim to study the impact of stereotactic radiosurgery, for the treatment of vestibular Schwannoma, on the cochlear, vestibular, gustatory, and facial nerve functions and compare it with a conservatively treated group. The predictive value of radiological tumor characteristics on hearing preservation and vestibular function will be also evaluated. Additionally, the investigators will invite patients with vestibular Schwannoma to fill out questionnaires to assess their quality of life.
Eligibility
Inclusion Criteria: * Aged 18 years or above * Patients with unilateral VS treated either with SRS or MRI-based observation strategy, as proposed by the institution's skull base tumor board independently of the study * Patients willing to take part in the study and give their informed consent Exclusion Criteria: * Previous surgical or radiation therapy for VS (including SRS) * Patients diagnosed with neurofibromatosis type II * Preexisting profound hearing loss, with a pure tone average (PTA) \>90 and word recognition score (WRS) \<10%, upon initial assessment * Previous middle ear surgery of the affected ear * Concurrent treatment with other experimental drugs
Conditions3
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NCT05641441