The Effects of Using Different Anesthetics on the Prognosis of Primary Lung Tumors and Its Mechanism of Action

Summary

This is a two-arm, parallel-group randomized clinical trial. Routine perioperative care would be performed in volunteers with primary early lung cancer. The study will enroll approximately 300 volunteers to compare the progression-free or overall survival in patients undergoing video-assisted thoracoscopic surgery (VATS) for primary lung tumors between propofol and sevoflurane for the maintenance of anesthesia.

Eligibility

Inclusion Criteria:

* eighteen to eighty-year-old
* ASA class I-III patients
* Received elective thoracic surgery for primary lung tumors under general anesthesia

Exclusion Criteria:

* mental disorder
* poor liver function
* pregnant or lactating women
* morbidly obese
* allergy to any of the drugs used in this study
* recurrent tumor or repeat surgery
* biopsy cases
* incomplete outcome-data
* palliative treatment after surgery
* simultaneous treatment of other malignancies
* emergency surgery
* presence of other malignant tumors
* combined propofol and inhalation anesthesia or other anesthetics, such as ketamine or dexmedetomidine
* diagnosed as benign lung tumor, or other metastatic lung tumor

Conditions4

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