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Sonographic Diaphragm Function in AECOPD

RECRUITINGSponsored by Isala
Actively Recruiting
SponsorIsala
Started2023-03-27
Est. completion2025-03
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05671198

Summary

The study will be conducted as a single-center, prospective cohort study. The primary objective of this study is to investigate the responsiveness of sonographic parameters of diaphragm to detect change in Borg score for dyspnea during hospitalisation for AECOPD without respiratory acidosis.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Hospitalisation primarily because of severe acute exacerbation of COPD
* COPD, according to GOLD 2018 definition
* Post-bronchodilator FEV1/FVC \< 0,70 and FEV1% \< 80%pred. within last 5 years

Exclusion Criteria:

* Respiratory acidosis (pH \< 7.35 ánd PaCO2 \> 6 kPA)
* Need for (non-)invasive ventilation based on other criteria (e.g. severe hypoxia) upon presentation.
* Established diagnosis of diaphragm diaphragm paralysis.
* Inability for diaphragm imaging (e.g. mechanical ventilation, or unable to follow vocal instructions).
* Those not able or unwilling to give written informed consent.
* Pregnant women

Conditions1

COPD

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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