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A Study of Pressure Waveform Analysis in Coronary Artery-II

RECRUITINGSponsored by National Taiwan University Hospital Hsin-Chu Branch
Actively Recruiting
SponsorNational Taiwan University Hospital Hsin-Chu Branch
Started2023-01-04
Est. completion2025-12-31
Eligibility
Age21 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05672706

Summary

The goal of this observational study is to test the feasibility of intracoronary adenosine administration during coronary flow reserve(CFR) and index of microcirculatory resistance(IMR) assessment in a population with angina. The main questions it aims to answer are: * Repeatability of CFR and IMR assessment while hyperemia with intracoronary adenosine was administered. * Evaluate the correlation of the intrinsic signal of coronary waveform versus physiologic ischemia, while defined by fractional flow reserve(FFR) and CFR respectively. * The predictive value of FFR, CFR, and IMR on major adverse cardiovascular outcomes in 3 years Participants will undergo FFR, CFR, and IMR assessments in the catheterization laboratory of the National Taiwan University Hospital Hsin-Chu Branch, then clinical events follow up for 3 years.

Eligibility

Age: 21 Years+Healthy volunteers accepted
Inclusion Criteria:

* Participants with angina

Exclusion Criteria:

* Severe valvular heart disease
* History of asthma
* Heart rate less than 50 beats per minute
* systolic blood pressure less than 90 mmHg

Conditions2

Heart DiseaseIschemic Heart Disease

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