Barrett's Esophagus and Esophageal Adenocarcinoma, Searching for Reliable Diagnostic RNA Plasma-based Biomarkers

Summary

This study is designed to perform a explorative search of the transcriptome to detect new circulating diagnostic sensitive and specific biomarkers in patients with Barrett's esophagus or esophageal adenocarcinoma.

Eligibility

Inclusion Criteria:

* Barrett's Esophagus with length \> 3cm OR esophageal adenocarcinoma histologically proven
* Adequate mental faculty, allowing to understand the proposed treatment protocol and provide informed consent
* Age over 18 years
* No other concurrent malignant disease
* No inclusion in other clinical trials interfering with the study protocol
* No concurrent chronic systemic immune or hormone therapy, except neoadjuvant chemotherapy
* Absence of any severe organ insufficiency
* No pregnancy or breast feeding
* Written informed consent

Exclusion Criteria:

* Pregnancy or breast feeding
* Active bacterial, viral or fungal infection
* Parenchymal liver disease (any stage cirrhosis)
* High risk of bleeding during biopsy (anticoagulants, esophageal varices)
* Esophageal squamous cell carcinoma
* Helicobacter pylori positive at the time of biopsy sampling
* Radiofrequency ablation of the oesophagus
* Psychiatric pathology capable of affecting comprehension and judgement faculty

Conditions2

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