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Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO

RECRUITINGPhase 1Sponsored by University Hospital, Lille
Actively Recruiting
PhasePhase 1
SponsorUniversity Hospital, Lille
Started2023-09-18
Est. completion2026-09-18
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05699005

Summary

This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock. An individualized transfusion strategy based on ScVO2 level, is compared to a conventionnal strategy based on predefined hemoglobin threshold. The primary endpoint is the consumption of packed red blod cells, secondary endpoints are subgroup analysis, mortality, morbidity, and cost-effectiveness

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Age of 18 and older,
* supported by peripheral VA-ECMO
* for cardiogenic shock
* Life expentency \>90 days
* Central venous line available ScVO2 measurement

Exclusion Criteria:

* Pregnancy,
* Lack of health insurance,
* Opposition to blood transfusion,
* Known congenital hemoglobin disease or disorder,
* Metabolic alcaloosis with pH\>7.8,
* eCPR,
* Legally incapacitated adults

Conditions6

AnemiaCardiogenic ShockExtracorporeal Membrane OxygenationHeart DiseaseOxygen DeliveryTransfusion Related Complication

Interventions1

Packed Red Blood Cells (PRBCs)

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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