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Imaging the Pathogenesis of Cerebral Small Vessel Disease

RECRUITINGSponsored by Johns Hopkins University
Actively Recruiting
SponsorJohns Hopkins University
Started2022-11-08
Est. completion2027-03-31
Eligibility
Age18 Years+
Locations1 site
View on ClinicalTrials.gov →

NCT05703386

Summary

Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.

Eligibility

Age: 18 Years+
Inclusion Criteria:

* Clinical or radiographic evidence of ischemic stroke
* One vascular risk factor (hypertension, hyperlipidemia, or diabetes)
* Evidence of cerebral small vessel disease on MRI

Exclusion Criteria:

* Inability to complete 3 research MRI scans over 1.25 years

Conditions4

DiabetesHyperlipidemiasHypertensionIschemic Stroke

Locations1 site

Kennedy Krieger Institute
Baltimore, Maryland, 21205
Pooja Patel410-502-5355ppate120@jhmi.edu

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