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Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease

RECRUITINGPhase 4Sponsored by Central Denmark Region
Actively Recruiting
PhasePhase 4
SponsorCentral Denmark Region
Started2025-06-02
Est. completion2027-05-31
Eligibility
Age40 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05703919

Summary

The STOP-COPD trial is a randomized, patient-blinded, prehospital clinical trial designed to evaluate the effect of titrated oxygen therapy compared to standard oxygen treatment in patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The primary objective is to determine whether a titrated oxygen strategy targeting SpO₂ 88-92% can reduce 30-day mortality compared to the current standard practice using 100% compressed oxygen as a nebulizer driver.

Eligibility

Age: 40 Years+Healthy volunteers accepted
Inclusion Criteria:

* Patients over the age of 40
* EMT or Paramedic suspected AECOPD
* Confirmed suspicion of COPD

Exclusion Criteria:

* Bronchospasm due to asthma, allergic reaction or non-COPD conditions
* Known or suspected pregnancy
* Prehospital Non-invasive, invasive or assisted bag mask ventilation
* Allergy to inhaled bronchodilators (Salbutamol)
* Inter-hospital transfer
* More than 2 doses (5 mg salbutamol) inhalation drug, acute treatment by EMS (emergency medical service) personnel, before allocated treatment is initiated
* Suspicion of acute coronary syndrome

Conditions3

COPDCOPD ExacerbationCOPD Exacerbation Acute

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