|

Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF

RECRUITINGN/ASponsored by University of Texas Southwestern Medical Center
Actively Recruiting
PhaseN/A
SponsorUniversity of Texas Southwestern Medical Center
Started2023-07-01
Est. completion2028-06-30
Eligibility
Age55 Years – 90 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT05723679

Summary

The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.

Eligibility

Age: 55 Years – 90 YearsHealthy volunteers accepted
Inclusion Criteria:

* signs and symptoms of heart failure
* an ejection fraction \> 0.50;
* objective evidence of diastolic dysfunction. elevated biomarkers (NT-proBNP \>300 ng/dl) or HF hospitalization
* healthy volunteers

Exclusion Criteria:

* age \< 55 years
* BMI \> 50 kg/m2
* Atrial fibrillation with poorly controlled heart rate
* phosphodiesterase type 5 (PDE5) inhibitor use
* severe valvular disease
* severe Chronic obstructive pulmonary disease (COPD)
* Chronic kidney disease (CKD) 4 or higher
* any restriction of ambulation and mobility.

Conditions3

Heart DiseaseHeart Failure With Preserved Ejection FractionObesity

Locations1 site

UT Southwestern Medical Center
Dallas, Texas, 75390
Raksa B Moran, RN214-345-6574raksamoran@texashealth.org

Browse More Trials

Heart Disease trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.