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Fluid Challenge and Plasma Volume, During Surgery

RECRUITINGPhase 4Sponsored by Joachim Zdolsek
Actively Recruiting
PhasePhase 4
SponsorJoachim Zdolsek
Started2023-10-23
Est. completion2025-10-31
Eligibility
Age18 Years – 80 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05726136

Summary

A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique. The purpose with the study is to examine the plasma expanding effect of three different fluid challenge strategies (acetated Ringers 4 ml/kg body weight, albumin 5% 4 ml/kg body weight or albumin 20% 1 ml/kg body weight), using hemoglobin as a dilution indicator.

Eligibility

Age: 18 Years – 80 YearsHealthy volunteers accepted
Inclusion Criteria:

* Written consent to participate in the study
* For women: relevant contraceptive, menopausal or a negative pregnancy test.
* ASA category I to III
* Laparoscopic abdominal surgery, with a duration of at least 90 minutes.
* 18 to 80 years

Exclusion Criteria:

* Patients with known cardiac failure
* \<18 or \>80 years
* known allergy to albumin
* extracellular hyperhydration or hypervolemia
* kidney failure
* pregnancy or planned pregnancy

Conditions6

Benign NeoplasmCancerColorectal CancerColorectal DisordersGynecologic CancerUrologic Cancer

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