Role of Fasted Exercise on Improving Cardiometabolic Health

Summary

The aim of this randomised control trial is to investigate the role of fasted exercise on cardiometabolic health. Participants will be assigned to one of three conditions, fasted exercise, fed exercise and control (no exercise). Participants in the exercise groups will complete four weeks of moderate intensity cycling exercise, three times per week, either in the fasted or fed state according to their group assignment. Experimental trials involving anthropometric and cardiometabolic disease risk factor measurements as well as metabolic responses to a subsequent meal ingestion following exercise will be compared pre-intervention and post intervention.

Eligibility

Inclusion Criteria:

* Male or female
* Non-smokers
* Physically inactive (partake in no more than one exercise session per week on average)
* Body mass index \>18.5 kg/m2
* Healthy as assessed by medical screening questionnaire
* Prior recipient of local anaesthetic with no known adverse effects, no known hypersensitivity or no other health issue that may constrain the administration of lidocaine hydrochloride
* Free from musculoskeletal injury and able to perform cycling exercise
* Capacity to give informed consent

Exclusion Criteria:

* Regular exerciser
* BMI \< 18.5 kg/m2
* Pregnant
* Allergy or intolerances to test meal products/ingredients (such as wheat or dairy products).
* Recent major body weight change (+/- 3 kg in the past month)
* Known hypersensitivity to Lidocaine Hydrochloride
* Cardiovascular disease - complete heart block or hypovolaemia
* Adam's-Stokes Syndrome
* Wolff-Parkinson-White Syndrome
* Porphyria
* Epilepsy
* Myasthenia Gravis
* Other chronic medical condition or diagnosis including respiratory (eg asthma), endocrine, cardiovascular, neuromuscular disorders.
* Taking medications or receiving treatment that may constrain the administration of lidocaine or local anaesthesia.

Conditions4

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