SPEECH as Biomarker for Emotion, Movement and cOgnition in Parkinson's Disease

Summary

With this study, the investigators want to investigate whether computerized speech analysis can be used to reliably and objectively detect motor, emotional, and cognitive fluctuations in Parkinson's disease patients.

Eligibility

Patients with Parkinson's Disease

Inclusion Criteria:

* Written informed consent
* Idiopathic PD according to the Movement Disorders Society Criteria;
* Age of participants \> 30 and ≤ 75 years;
* Treatment with or without bilateral deep brain stimulation in the subthalamic nucleus;
* Fluent in German or French

Exclusion Criteria:

* Dysarthria caused in addition by a condition other than PD (e.g. stroke, myasthenia);
* Clinical diagnosis of aphasia;
* Brain disease other than Parkinson's disease (e.g. atypical Parkinsonism, Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, epilepsy, etc.).
* Cognitive impairment (Montreal Cognitive Assessment (MoCa) \< 24/30 points);
* Depression with acute suicidal ideation

Healthy Controls

Inclusion Criteria:

* Written informed consent
* Adults from 50-70 years old;
* Fluent in German or French

Exclusion Criteria:

* Diagnosis of Parkinson's disease;
* Cognitive impairment (Montreal Cognitive Assessment (MoCa) \< 24/30 points);
* Suffering from brain disease (e.g. atypical Parkinsonism, Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, epilepsy, etc.);
* Clinical diagnosis of aphasia, dysarthria, and stuttering;
* Suffering from or diagnosed with psychiatric illnesses according to DSM-V criteria

Conditions2

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