Cardiovascular and Venous Thromboembolism Disease in Patients with Von Willebrand Disease in the French West

Summary

Due to increasing of life expectancy, patients with von Willebrand disease are exposed to age-related pathologies such as cancer or cardiovascular diseases. Management of thrombotic events is challenging given the inherent bleeding risk in von Willebrand disease. Few data are currently available in the literature. The aim of the study is to describe the frequency and nature of arterial and venous thromboembolic events and atrial fibrillation in patients with von Willebrand disease in the West of France. The investigators will perform a retrospective multicenter study conducted in the von Willebrand population of the French West. Von Willebrand adult patients followed in one of the French West medical centers participating in the study, who presented deep vein thrombosis, pulmonary embolism, ischemic stroke, transient ischemic attack, acute coronary syndrome, acute limb ischemia, atrial fibrillation, arteriopathy of the lower limbs, angina will be eligible.

Eligibility

Inclusion Criteria:

* Von Willebrand disease
* Adult
* Followed-up in a reference center of West of France (Caen, Brest, Nantes, Rennes, Le Mans, Angers)
* Consented to be included in BERHLINGO database
* Have presented a thrombotic and/or embolic event or cardiovascular disease including deep vein thrombosis, pulmonary embolism, ischemic stroke, transient ischemic attack, acute coronary syndrome, acute limb ischemia or angina or obliterating arteriopathy of the lower limbs, atrial fibrillation.
* Have not expressed their opposition

Exclusion Criteria:

* \- Expression of opposition
* Acquired von Willebrand syndrome
* Patients under legal protection
* Minor

Conditions2

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