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The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck

RECRUITINGSponsored by Royal Marsden NHS Foundation Trust
Actively Recruiting
SponsorRoyal Marsden NHS Foundation Trust
Started2023-09-08
Est. completion2028-04-30
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05808920

Summary

The RESCUE study is a combined retrospective and prospective multicentre cohort study investigating the survival and functional outcomes in patients undergoing salvage surgery for recurrent, residual, and new primary head and neck squamous cell carcinoma (SCC). Additionally, the RESCUE study will contain an exploratory molecular analysis of consenting patients to assess the relationship between cancer genomics, previous radiotherapy, and recurrence in head and neck cancer.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

1. Aged over 18
2. Previous H\&N SCC treated with radiotherapy with or without chemotherapy
3. Local or regionally recurrent, residual, or new primary SCC of the oropharynx, oral cavity, larynx, and hypopharynx
4. Ability to give informed consent for biological sample collection (molecular analysis study only)

Exclusion Criteria:

1. Nasopharyngeal and cutaneous SCC of the H\&N
2. Thyroid, salivary gland, and non-squamous cell H\&N cancers
3. Presence of distant metastasis (M1) or surgically inoperable T4b tumours

Conditions2

CancerHead and Neck Cancer

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