Investigating Neural Biomarkers for Gait in Parkinson's Patients

Summary

This observational study's main goal is to learn more about the neural mechanisms during movement in Parkinson's disease. Furthermore, it aims to inspire personalised treatment options. Participants will undergo a protocol that involves walking and gait-related motor tasks, such as seated stepping. During the protocol, brain activity will be recorded.

Eligibility

Inclusion Criteria:

All participants

* must have given informed consent as documented by signature
* agree to comply with the study procedures

Healthy control group

* no neurological, orthopedic, or rheumatologic disease history
* no identified sensory impairment.
* no epilepsy and self-diagnosed acute or chronic psychiatric disorders

Parkinson's Patients

* non-tremor dominant idiopathic PD patients
* presence of postural instability (UPDRS \>1 for postural instability \[17\]), gait disturbance, and absence of other causes of reduced balance
* Implanted with Percept™ PC neurostimulator
* Able to be in the stimulation OFF

Exclusion Criteria:

* Relevant cognitive impairment, with a score on Montréal Cognitive Assessment (MoCA) \< 20
* History of physical or neurological condition that interferes with study procedures
* Social and/or personal circumstances interfering with the ability to come to the session

Conditions3

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