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Coronary Flow During Rapid Heart Rates

RECRUITINGSponsored by Imperial College London
Actively Recruiting
SponsorImperial College London
Started2023-08-01
Est. completion2026-06-02
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05841199

Summary

The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are: 1. What impact does coronary artery disease have on the ability for a patient to tolerate VT? 2. Does treatment of coronary artery disease with stents improve the tolerability of VT? Participants who are undergoing a clinically indicated coronary angiogram or coronary angioplasty procedure will have measurements of blood pressure, coronary pressure and coronary flow made during pacing at a range of heart rates.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Able to give valid consent
* Referred for coronary angiography or coronary angioplasty
* Suitable for percutaneous physiological interrogation and PCI when clinically indicated

Exclusion Criteria:

* Unable to give valid consent
* Pregnant or breastfeeding women
* Unstable coronary artery disease (acute coronary syndrome)
* Severe multivessel coronary artery disease suitable for coronary artery bypass grafting
* Severe heart valve disease
* Severe (NYHA IV) heart failure

Conditions6

Coronary Artery DiseaseCoronary Microvascular DiseaseCoronary Microvascular DysfunctionHeart DiseaseHeart FailureVentricular Tachycardia

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