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Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals

RECRUITINGN/ASponsored by Steno Diabetes Center Copenhagen
Actively Recruiting
PhaseN/A
SponsorSteno Diabetes Center Copenhagen
Started2026-01-01
Est. completion2026-12
Eligibility
Age35 Years – 40 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05842850

Summary

The investigators will conduct a proof-of-principle 4-weeks low-calorie diet (LCD) intervention study in low birth weight (LBW) subjects and normal birth weight (NBW) controls with documented (MR scan) liver fat content equal to or above 5%. The investigators will provide extended in-depth mechanistic insight into the role of impaired subcutaneous adipose tissue (SAT) expandability in ectopic fat deposition before and after LCD.

Eligibility

Age: 35 Years – 40 YearsHealthy volunteers accepted
Inclusion Criteria:

* subjects with NAFLD (liver fat content ≥5% liver fat content verified on MRS in the screening NAFLD study)

Exclusion Criteria:

* BMI\<18.5 and BMI\>30 kg/m2
* Family history of diabetes (siblings, parent, and grandparents)
* Disease/medication known to affect primary outcome
* Self-reported high physical activity level
* Alcohol intake above general recommendations.
* Metabolic/liver disease
* Weight gain/loss of \>3 kg within the past 6 months

Conditions2

Liver DiseaseNAFLD

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