Disentangling the Role of Depression in Hypersomnia

Summary

Individuals who have disorders of hypersomnolence (excessive sleepiness) often report symptoms of depression. The goal of this study is to further understand of the relationship between depression and hypersomnia by examining mood-relevant domains of slow wave sleep and reward function.

Eligibility

Inclusion Criteria:

* Males and females between the age of 21 and 55
* Meet DSM5 criteria for Idiopathic Hypersomnia or Hypersomnia Associated with a Psychiatry Disorder
* Ability to read and speak English

Exclusion Criteria:

* Unable or unwilling to provide informed consent
* Untreated obstructive sleep apnea (apnea-hypopnea index /= 15 events/hr)
* Meeting diagnostic criteria for narcolepsy
* A clinically unstable medical condition as defined by a new diagnosis or change in medical management in the previous 2 months (e.g., pneumonia, thyroid disease, ventricular arrhythmias, cirrhosis, surgery, or recently diagnosed cancer) because these changes could impact daytime hypersomnia and confound results
* Substance abuse/dependence, delirium, dementia, amnestic disorder, schizophrenia, and other psychotic disorders
* Prominent current suicidal or homicidal ideation.
* Unable to perform tests due to inability to communicate verbally, inability to read and write; less than a 5th grade reading level; visal, hearing, or cognitive impairment (e.g. previous head injury)
* Use of medications or OTC products that might impact sleep

Conditions2

Locations1 site

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