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buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

RECRUITINGPhase 2Sponsored by University of California, San Francisco
Actively Recruiting
PhasePhase 2
SponsorUniversity of California, San Francisco
Started2023-08-07
Est. completion2026-11-30
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT05851391

Summary

RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

1. Age ≥18 years old
2. Non-traumatic, out-of-hospital cardiac arrest
3. Comatose on admission - defined as not following commands
4. Return of spontaneous circulation (ROSC) within less than 45 minutes
5. Admission to the intensive care unit
6. Diagnosis of post-cardiac arrest refractory status epilepticus confirmed with continuous

EEG monitoring within 7 days from ROSC

Exclusion Criteria:

1. Acute cerebral hemorrhage or infarction
2. Pregnancy
3. Prisoners

Conditions8

Anoxia-Ischemia, CerebralAnoxic-Ischemic EncephalopathyHeart ArrestHeart DiseaseHypoxia-Ischemia, BrainRefractory Status EpilepticusSeizuresStatus Epilepticus

Locations1 site

Zuckerberg San Francisco General Hospital
San Francisco, California, 94110
Edilberto Amorim, MD

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