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Stimulation-Induced Changes in Fronto-Limbic Network

RECRUITINGN/ASponsored by University of Alabama at Birmingham
Actively Recruiting
PhaseN/A
SponsorUniversity of Alabama at Birmingham
Started2023-03-01
Est. completion2026-02-28
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT05854160

Summary

The purpose of this research is to better understand how emotion processing unfolds in the brain using stereoelectroencephalography (sEEG) and direct brain stimulation. This study will use standard behavioral emotion processing tasks combined with neural recording and direct brain stimulation to assess different aspects of emotion processing. Stimulation pulses during pre and post-test periods will assess the effects of stimulation before and after conditioning, the results of which will be combined with results from the activity of each electrode during the emotion tasks to inform us of the nature of emotion processing in the brain and allow us to devise brain modulation protocols in the future.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* 1\) implantation of sEEG electrodes for SOC epilepsy surgery evaluation
* 2\) cognitive ability to perform simple tasks and to understand instructions
* 3\) implanted electrodes in the amygdala and medial PFC regions
* 4\) competency to understand and sign a written informed consent.

Exclusion Criteria:

* 1\) an inability to complete the task

Conditions3

AnxietyEpilepsyMental Disorders

Locations1 site

Epilepsy Monitoring Unit UAB Hospital
Birmingham, Alabama, 35233
Rebekah Chatfield, BS(205) 975 3477Joyb3@uab.edu

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