The Impact of Beef on Muscle Fatigue in Older Adults
NCT05860088
Summary
The goal of this controlled-feeding cross-over diet intervention is to compare a beef diet to a vegetarian diet on muscle fatigue in older adults. The aims are: AIM 1: To test the hypothesis that muscle fatigue is attenuated in older adults consuming beef compared to older adults consuming a plant-based diet. AIM2: To test the hypothesis that daily beef consumption improves biochemical indicators related to muscle fatigue. Participants will be randomized to consume either a beef-based diet or vegetarian diet under controlled-feeding conditions for 8 weeks. After a 2-week washout period, participants will cross-over to consume either the beef diet or vegetarian diet for 8 weeks. Body composition and functional muscle outcomes will be measured during each 8-week feeding period. Blood samples will also be collected.
Eligibility
Inclusion Criteria * Ages 60-85 years * Ability to eat study diet meals for a total of 16 weeks * Ability to perform sit-to-stand chair and 6-minute walking tests based on results from PAR-Q questionnaire * Ability to provide fasted blood samples * Access to transportation * Willing to abstain from alcohol consumption and/or use illicit drug use for each 8-week intervention period * Ability to consent to participating in this study * English-speaking * Body mass index between 18.5 (normal) and 39.9 (obese) kg/m2 * Minimum total body weight of 110 pounds * Non-anemia hemoglobin values: Females - \>12.0 grams/dL; Men - \>13.0 grams/dL * Able to ambulate without assistance * Physician's clearance for study participation (required prior to baseline testing) Exclusion Criteria * Inability or refusal to sign the informed consent * Significant orthopedic limitations or other contraindications to exercise * Inability or refusal to perform muscle fatigue tests * Has dietary restrictions that prevent to consumption of beef, soy and/or wheat * Has liver or kidney complications * Live or work \>25 miles from Bloomington study site or does not have transportation to the study site * Anticipate elective surgery during the study period * Diagnosis of progressive neurological disorders, musculoskeletal disorders, osteoarthritis, rheumatoid arthritis * Fracture or serious injury in the last 6 months * Stroke, revascularization, deep vein thrombosis, or pulmonary embolism in the past 12 months * Severe cardiovascular disease, uncontrolled systemic hypertension, chronic pulmonary disease * Plan to move residence or travel out of the local area during the study period * Current use of anti-coagulants (e.g. Coumadin or Warfarin) * Current use of prescription medications that affect heart rate or blood vessel dilation * Psychological or social characteristics that would interfere with their ability to fully participate in the study
Conditions4
Locations1 site
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NCT05860088