Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation

Summary

The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery.

Eligibility

Inclusion Criteria:

1. U.S. Veteran
2. Self-reported COVID-19 naïve or COVID-19 \> 90 days ago for lean and obese PCC naïve or documented COVID-19 for the lean and obese PCC groups (At least one PCC symptom \>4 weeks)
3. Body Mass Index: 19-25 or 30-50 kg/m2

Exclusion Criteria:

1. Neurologic, musculoskeletal, or other condition that limits subject's ability to complete study physical assessments
2. Active inflammatory, COVID-19, autoimmune, infectious, hepatic (LFTs \> 2.5 x WNL), renal (eGFR\<45), gastrointestinal, malignant, and psychiatric disease
3. Uncontrolled diabetes (HbA1c \>10% or the current use of insulin)
4. Weight change within the past month of \>5 kg
5. Self-reported alcohol or drug abuse
6. Anti-coagulant medication usage

Conditions3

Locations2 sites

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