The PRECISION-T2D Study: Precision Nutrition Study for Type 2 Diabetes

Summary

Food plays a crucial role in determining blood glucose levels, especially in people with type 2 diabetes. Precision nutrition, which involves individually tailored dietary interventions, can be a powerful tool in managing blood glucose levels in people with type 2 diabetes. Previous studies found that changes in gut microbiota resulted from the dietary intervention, such as plant-based diet, might subsequently lead to different glycemic responses, and then different health outcomes. In this study, the investigators will characterize the blood glucose dynamics and gut microbiota of individuals with type 2 diabetes. They aim to assess the influence of plant-based diet on gut microbiota; they will also investigate the influence of gut microbiota on glycemic responses. Additionally, a series of individual N-of-1 trails will be integrated to compare the effects of a white bread breakfast and a whole wheat bread breakfast on glucose metabolism at the individual level.

Eligibility

Inclusion Criteria:

* Diagnosed with type 2 diabetes;
* Living in Hangzhou for at least five years;
* Have the willingness or ability to complete the intervention and sample collection

Exclusion Criteria:

* Mental and physical disability;
* Already is a vegetarian;
* Cancer and serious complications from type 2 diabetes, such as renal failure;
* Using insulin for more than 5 years;
* Unstable medical/medication status;
* Current alcohol or drug abuse;
* Taking antibiotics in the last three months

Conditions2

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