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Increased Risk of Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals

RECRUITINGSponsored by Steno Diabetes Center Copenhagen
Actively Recruiting
SponsorSteno Diabetes Center Copenhagen
Started2023-12-14
Est. completion2025-08
Eligibility
Age35 Years – 40 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05890365

Summary

The investigators recently demonstrated a increase in liver fat in early middle-aged LBW compared to normal birth weight (NBW) men, and 20% of the LBW - but none of the normal birth weight (NBW) - men had previously unknown non-alcoholic fatty liver disease (NAFLD). Here the investigators will further examine the Increased risk of non-alcoholic fatty liver disease in low birth weight individuals by performing a validation study.

Eligibility

Age: 35 Years – 40 YearsHealthy volunteers accepted
Inclusion Criteria:

* 250 healthy, men and women born with a low birth weight (birth weight (BW) \<10% of the population) and 50 born with a normal birth weight controls (BW between 50-90% of the population)
* born at term (weeks 39-41)

Exclusion Criteria:

* BMI\>35 kg/m2
* Disease/medication known to affect primary outcome
* Self-reported high physical activity level
* Alcohol intake above general recommendations.
* Metabolic/liver disease
* Weight gain/loss of \>3 kg within the past 6 months

Conditions3

Liver DiseaseLow Birth WeightNon Alcoholic Fatty Liver Disease

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