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Immune Function and the Progression to T1D

RECRUITINGSponsored by University of Florida
Actively Recruiting
SponsorUniversity of Florida
Started2005-01-01
Est. completion2085-01-01
Eligibility
Age0 Years – 100 Years
Healthy vol.Accepted
Locations3 sites
View on ClinicalTrials.gov →

NCT05899439

Summary

To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune cells, defective regulatory/effector mechanisms in T cells, inflammatory antigen presenting cells, and abnormal immune function in T cells and B cells.

Eligibility

Age: 0 Years – 100 YearsHealthy volunteers accepted
Inclusion Criteria: able to have blood drawn -

Exclusion Criteria: none

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Conditions2

DiabetesType 1 Diabetes

Locations3 sites

Florida

1 site
Kieran McGrail
Gainesville, Florida, 32610
Kieran McGrail352-273-9299mcgrail@pathology.ufl.edu

Ohio

1 site
The Ohio State University
Columbus, Ohio, 43210
Billur Akkaya, MD DPhil614-688-1187billur.akkaya@osumc.edu

Texas

1 site
Baylor College of Medicine, Center for Research Advancement - Texas Children's Hospital
Houston, Texas, 77030
Maria Redondo, MD, PhD, MPH832-822-1019redondo@bcm.edu

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