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Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

RECRUITINGSponsored by Washington University School of Medicine
Actively Recruiting
SponsorWashington University School of Medicine
Started2023-03-07
Est. completion2027-07-31
Eligibility
Age21 Years – 65 Years
Locations1 site
View on ClinicalTrials.gov →

NCT05905705

Summary

Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.

Eligibility

Age: 21 Years – 65 Years
Inclusion Criteria:

* Referral for initial ECT index course for Treatment-Resistant Depression (TRD), unipolar major depressive disorder or bipolar depression. Historic failure of response or remission to at least two antidepressant medications of sufficient dose and duration will be used for TRD diagnostic.

Exclusion Criteria:

* Diagnoses of schizophrenia or schizoaffective disorders.
* Subjects who are unable to tolerate the Dreem device for sleep recordings will be excluded from the study.

Conditions2

DepressionTreatment-resistant Depression

Locations1 site

Washington University School of Medicine/Barnes-Jewish Hospital
St Louis, Missouri, 63110
Robby Greenspan314-273-6129greenspan@wustl.edu

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