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ITreatOCD: Predicting the Efficacy of Internet-based Cognitive Behavioral Therapy in Obsessive-compulsive Disorder

RECRUITINGN/ASponsored by Pedro Morgado
Actively Recruiting
PhaseN/A
SponsorPedro Morgado
Started2023-05-02
Est. completion2025-09
Eligibility
Age18 Years – 65 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05906069

Summary

In the current study, the investigators will characterize obsessive-compulsive disorder (OCD) patients and healthy controls with a comprehensive clinical and neuroimaging assessment, focusing on the basic psychological processes related and on the neurobiological underpinnings of emotion regulation (ER). After a baseline assessment, the investigators will implement an internet-based cognitive behavioral therapy (iCBT) protocol and assess its efficacy on the modulation of ER and OCD severity. Specifically, the investigators will (1) examine to what extent the iCBT intervention modulates ER and the associated neurobiological mechanisms and (2) identify candidate biomarkers of successful treatment response.

Eligibility

Age: 18 Years – 65 YearsHealthy volunteers accepted
Inclusion Criteria:

* Primary diagnosis of current OCD according to the fifth Diagnostic and Statistical Manual of Mental Disorders
* YBOCS score ≥ 16
* Psychotropic medication, if stable for at least 2 months prior to inclusion and if the dosage is maintained thoughout the study
* Have the resources to access the online intervention (internet access; computer or tablet)

Exclusion Criteria:

* MRI contraindications
* Prior medical history of neurological disorders or traumatic brain injury
* Having performed CBT treatment for OCD in the last 2 years
* Undergoing any psychological treatment
* Suicidal ideation
* Current alcohol or drug abuse

Conditions2

AnxietyObsessive-compulsive Disorder

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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