|

(Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma

NOT_RECRUITINGPhase 2Sponsored by IDEAYA Biosciences
No longer actively recruiting
PhasePhase 2
SponsorIDEAYA Biosciences
Started2023-07-03
Est. completion2027-04-30
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations13 sites
View on ClinicalTrials.gov →

NCT05907954

Summary

Neoadjuvant/adjuvant IDE196 (darovasertib) in patients with primary uveal melanoma

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Primary localized uveal melanoma requiring either enucleation or plaque brachytherapy
* Cohort 3 (patients with small UM tumors) - clinically diagnosed uveal (not iris) melanoma that is \< 4 mm in thickness requiring treatment
* Able to dose orally
* ECOG Performance status of 0-1
* No other significant underlying ocular disease
* Adequate organ function
* Not pregnant/nursing or planning to become pregnant. Willing to use birth control

Exclusion Criteria:

* Previous treatment with a Protein Kinase C (PKC) inhibitor
* Concurrent malignant disease
* Active HIV infection or Hep B/C
* Malabsorption disorder
* Unable to discontinue prohibited medication
* Impaired cardiac function or clinically significant cardiac disease
* Any other condition which may interfere with study interpretation or results

Conditions2

CancerUveal Melanoma

Interventions1

Darovasertib

Locations13 sites

HonorHealth Research Institute
Scottsdale, Arizona, 85258
(480) 323-1791clinicaltrials@honorhealth.com
Moores Cancer Center
La Jolla, California, 92093
Catherine O'Neil(858) 822-6575croneil@health.ucsd.edu
UCLA Medical Center
Los Angeles, California, 90024
Adyel Annelus310-794-4955aannelus@mednet.ucla.edu
Stanford Cancer Institute
Palo Alto, California, 94305
Claire A Billman, B.S650-736-6425cbillman@stanford.edu
Sarah Cannon Research Institute
Denver, Colorado, 80218
Sarah Cannon720-754-2610cann.ddudenvergeneral@sarahcannon.com

Find trials near these locations

All trials in ArizonaAll trials in CaliforniaAll trials in ColoradoAll trials in FloridaAll trials in MinnesotaAll trials in New YorkAll trials in North CarolinaAll trials in PennsylvaniaAll trials in TennesseeAll trials in Texas

Related trials

Browse More Trials

Cancer trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.