Relationship Between Glycemic Control and Irisin in Type 2 Diabetic Patients With Sarcopenic or Non-sarcopenic Obesity

Summary

The goal of this observational study is to compare glycemic control and irisin levels in subjects with diabetes mellitus type 2 with sarcopenic obesity vs non-sarcopenic obesity. The main questions it aims to answer are: Is glycemic control worse in diabetic patients with sarcopenic obesity? Are irisin levels higher in patients with non-sarcopenic obesity? Participants will be asked to: * Fill in three questionaries on lifestyle * Perform two physical performance tests The investigators will collect the following data: * Anthropometric measurements * Body composition by bioelectrical impedance analysis. * Results of routine blood analyses * Irisin levels by drawing a vial of blood from the antecubital vein

Eligibility

Inclusion Criteria:

* Diabetes mellitus type 2 diagnosed less than 10 years before
* age \>60 years
* BMI (Body Mass Index) \>30 kg/m2
* eGFR (estimated Glomerular Filtration Rate) \>30 ml/min
* On stable antidiabetic therapy for at least 3 months

Exclusion Criteria:

* Insulin or insulin secretagogues use
* Diabetes mellitus type 1, previous diabetic ketoacidosis
* Neuromuscular diseases
* Endocrinopathies that may cause myopathies (hypercortisolism, GH \[growth hormone\] deficiency, acromegaly, adrenal insufficiency, partial hypopituitarism or panhypopituitarism, male hypogonadism, hyperparathyroidism, hypoparathyroidism)
* Severe vit. D deficiency (\<12 ng/ml)
* Hemoglobinopathies
* Prolonged immobilization
* Pathologies with fluid retention (heart failure with NYHA \[New York Heart Association\] class III/IV, severe renal insufficiency, hepatic insufficiency)
* Active tumors in the past 5 years
* Severe arthritis of the knee or hip
* Pacemaker wearer

Conditions4

Browse More Trials