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Hypertonic Saline Solution to Prevent Acute Kidney Injury After Heart Transplantation

RECRUITINGPhase 2Sponsored by Fernando Bacal
Actively Recruiting
PhasePhase 2
SponsorFernando Bacal
Started2023-11-08
Est. completion2026-12
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT05909150

Summary

The goal of this study is to evaluate if hypertonic saline solution can prevent or attenuate acute kidney injury after heart transplantation in the early postoperative phase.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Hospitalized patients submitted to orthotopic heart transplantation (HT)

Exclusion Criteria:

* Requirement of renal replacement therapy at the time of HT
* Requirement of extracorporeal membrane oxygenation (ECMO) before or immediately after HT
* Severe peri-operative mechanical complications
* Double transplant (e.g. heart-kidney or heart-lung)
* Hypernatremia (Na ≥ 145)
* Severe hyponatremia (Na ≤ 120)

Conditions3

Acute Kidney InjuryHeart DiseaseHeart Transplantation

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