Evaluation of the Diagnostic Performance of Dynamic Myocardial Perfusion Scintigraphy in Comparison With Invasive Intracoronary FFR Measurement, in the Assessment of Significant Residual Coronary Stenosis After Acute Coronary Syndrome: Dyna-MI Pilot Study.

Summary

Dynamic 99mTc-Tetrofosmin CZT-SPECT myocardial perfusion imaging (MPI) is an advanced functional imaging technique giving important myocardial flow quantification added data in comparison with conventional MPI, especially in coronary multi vessel disease. A large-scale validation of diagnostic performances of myocardial flow reserve (MFR) estimated with Dynamic 99mTc-Tetrofosmin CZT-SPECT MPI would allow a non-invasive approach instead of invasive intra-coronary fractional flow reserve (FFR) measurement. The aim of this prospective study is to assess diagnostic performances of MFR calculated with dynamic 99mTc-Tetrofosmin CZT-SPECT MPI in comparison with invasive intra-coronary FFR measurement in patients with significant residual coronary arteries stenosis after acute coronary syndrome .

Eligibility

Inclusion Criteria:

* Adult patient.
* Multi vessel coronary arteries disease (at least one non-culprit coronary stenosis \>= 50%) diagnosis during

  * primary percutaneous coronary intervention \< 12h after ST-elevation myocardial infarction opercutaneous revascularisation of the culprit lesion within 24 to 48 hours of an acute non-ST-segment elevation coronary syndrome.
* Written consent.
* Social security affiliation

Exclusion Criteria:

* Non adult patient.
* Adult patient under tutelage.
* Reproductive age women.
* Medical history of myocardial infarction or coronary artery bypass surgery.
* Cardiogenic shock.
* Cardiomyopathy.
* Regadenoson/adenosine/FFR contraindication.
* 99mTc-Tetrofosmin hypersensibility.
* Small non-culprit coronary arteries.
* Participation to another interventional study.

Conditions2

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